陈婷婷-yb体育官方
师资介绍
姓名:陈婷婷
性别:女
民族:汉
出生年月:1989年5月1日
职称:副教授
学历:博士
职务:无
研究方向:神经药理
基金项目:
1.国家自然科学基金,青年基金,81901098,抑制ras法尼基化改善阿尔兹海默病认知功能的分子机制研究,2020–01至2022–12,20.50万,在研,主持。
2.江苏省自然科学基金,青年基金,bk20190923,抑制ras 法尼基化抗痴呆的神经保护作用机制研究,2019–07至2022–6,20万,在研,主持。
3.市科学计划项目,jc2018009,小g 蛋白ras 活性抑制对阿尔兹海默病认知功能的调控机制,2018–07至2020–06,5万,结题,主持
科研成果:
代表性论文:
(1)cai c, wang l, li s, lou s, luo j, fu d, chen t*(通讯作者). ras inhibitor lonafarnib rescues structural and functional impairments of synapses of aβ 1-42 mice via α7nachr-dependent bdnf upregulation. j neurosci. 2022 aug 3;42(31):6090-6107. (一区)
(2)yang c, ni h, yin j, zhou t, gu q, chen t*, cai c*(共同通讯作者). atorvastatin ameliorates depressive behaviors via regulation of α7nachr expression by pi3k/akt-bdnf pathway in mice. biochem biophys res commun. 2022 feb 19;593:57-64. pmid: 35063770. (三区)
(3)wee meng lim, eunice w m chin, bor luen tang, tingting chen*, eyleen l k goh*(共同通讯作者). wnk3 maintains the gabaergic inhibitory tone, synaptic excitation and neuronal excitability via regulation of kcc2 cotransporter in mature neurons. front mol neurosci. 2021 nov 10;14:762142. (二区)
(4)chen tingting*; cai chengyun; wang lifeng; li shixin; chen ling *(第一作者兼通讯作者); farnesy transferase inhibitor lonafarnib enhances α7nachr expression through inhibiting dna methylation of chrna7 and increases α7nachr membrane trafficking, frontiers in pharmacology, 2020, 11. (二区)
(5)chen tingting#; wang ya#; zhang tingting; zhang baofeng; chen lei; zhao liandong; chen ling*(第一作者); simvastatin enhances activity and trafficking of α7 nicotinic acetylcholine receptor in hippocampal neurons through pkc and camkii signaling pathways, frontiers in pharmacology, 2018, 9: 362. (二区)
(6)chen tingting; tanaka motoki; wang ya; sha sha; furuya kishio; chen ling*; sokabe m*(第一作者); neurosteroid dehydroepiandrosterone enhances activity and trafficking of astrocytic glt-1 via σ1 receptor-mediated pkc activation in the hippocampal dentate gyrus of rats, glia, 2017, 65: 1491-1503. (二区)
(7)chen tingting; wang conghui; sha sha; zhou libin; chen lei*; chen ling*(第一作者); simvastatin enhances spatial memory and long-term potentiation in hippocampal ca1 via upregulation of α7nicotinic acetylcholine receptor, molecular neurobiology, 2016, 53: 4060-4072. (二区)
(8)chen tingting; zhang baofeng; li guoxi; chen lei; chen ling*(第一作者); simvastatin enhances nmda receptor glun2b expression and phosphorylation of glun2b and glun2a through increased histone acetylation and src signaling in hippocampal ca1 neurons, neuropharmacology, 2016, 107: 411-421. (二区)