刘兆国-yb体育官方

师资介绍

刘兆国，男，汉，1987年11月生，博士，副教授，硕士研究生导师

研究方向：

消化系统疾病（结肠癌、肝纤维化）的发病机理与中药复方及活性成分干预研究

主持科研项目：

（1）国家自然科学基金委员会，面上项目，82374228，乌梅丸通过ahcy蛋白介导rig-i乳酸化修饰调控巨噬细胞极化抗cac的作用及机制研究，2024/01-2027/12，49万元，在研，主持

（2）国家自然科学基金委员会，青年基金，81703884，基于pkcδ介导的自噬调控探究黄葵胶囊对顺铂肾毒性的保护作用及分子机制，2018/01-2020/12，20万元，已结题，主持

（3）中国博士后科学基金会，面上项目，2018m642296，黄葵胶囊抗顺铂所致肾毒性的机理研究，2018/11-2020/08，5万元，已结题，主持

（4）江苏省教育厅，高等学校(自然科学)研究面上项目，17kjb360012，黄葵胶囊对顺铂肾毒性的保护作用及机理研究，2017/09-2019/08，3万元，已结题，主持

（5）南通市科技局，科技计划项目，jc2021025，基于 mif/miox/铁死亡信号调控探究黄葵胶囊抗顺铂急性肾损伤的机制研究，2021/07-2023/06，5万元，已结题，主持

代表性论文：

（1）zirong deng^#, yun xu^#, yuchen cai, weiling lin, libei zhang, aoqing jiang, yuhang zhou, rui zhao, heyan zhao, zhaoguo liu^*（通讯作者） and tingdong yan^*.  [j]. international journal of molecular sciences, 2023, 24(4): 3528.

（2）, zhaoguo liu^*（通讯作者）. farnesoid x receptor activation is required for the anti-inflammatory and anti-oxidative stress effects of alisol b 23-acetate in carbon tetrachloride-induced liver fibrosis in mice [j]. international immunopharmacology, 2023, 123:110768.

（3）jue wang^#, kang ding^#, yuhang wang^#, tingdong yan, yun xu, zirong deng, weiling lin, libei zhang, weizhong zhu, rui zhao, yuhang zhou, zhaoguo liu^*（通讯作者）. wumei pill ameliorates aom/dss-induced colitis-associated colon cancer through inhibition of inflammation and oxidative stress by regulating s-adenosylhomocysteine hydrolase- (ahcy-) mediated hedgehog signaling in mice [j]. oxidative medicine and cellular longevity, 2022, 2022:4061713.

（4）zhaoguo liu^#（第一作者）, mengjue tu^#, jiannan shi^#, hong zhou, guoliang meng, jianguo gu^*, yuqin wang^*. inhibition of fucosylation by 2-fluorofucose attenuated acetaminophen-induced liver injury via its anti-inflammation and anti-oxidative stress effects [j]. frontiers in pharmacology, 2022, 13:939317.

（5）chang chen^#, jingya gu^#, jue wang^#, yu wu, aihua yang, tingting chen, tingting zhou, zhaoguo liu^*（通讯作者）. physcion 8-o-β-glucopyranoside ameliorates liver fibrosis throughinflammation inhibition by regulating sirt3-mediated nf-κb p65nuclear expression [j] international immunopharmacology, 2021, 90: 107206.

（6）yuqin wang^#, chunling li^#, jingya gu ^#, chang chen, jiaxin duanmu, jing miao, wenjuan yao, jinhua tao, mengjue tu, biao xiong, lingling zhao^*, zhaoguo liu^*（通讯作者）. celastrol exerts anti-inflammatory effect in liver fibrosis via activation of ampk-sirt3 signaling [j]. journal of cellular and molecular medicine, 2020, 24(1): 941-953.

（7）jingya gu^#, chang chen^#, jue wang#, tingting chen, wenjuan yao, tingdong yan^*, zhaoguo liu^*（通讯作者）. withaferin a exerts preventive effect on liver fibrosis through oxidative stress inhibition in a sirtuin 3-dependent manner [j]. oxidative medicine and cellular longevity, 2020, 2020: 2452848.

（8）jinlin zhang, aihua yang, yu wu, wei guan, biao xiong, xiaoqing peng, xiaojin wei, chang chen, zhaoguo liu^*（通讯作者）. stachydrine ameliorates carbon tetrachloride-induced hepatic fibrosis by inhibiting inflammation, oxidative stress and regulating mmps/timps system in rats [j]. biomedicine & pharmacotherapy, 2018, 97:1586-1594.

（9）zhaoguo liu^#,*（通讯作者）, pingting zhu^#, lin zhang, biao xiong, jinhua tao, wei guan, chunling li, chang chen, jingya gu, jiaxin duanmu, wei zhang ^*. autophagy inhibition attenuates the induction of anti-inflammatory effect of catalpol in liver fibrosis [j]. biomedicine & pharmacotherapy, 2018, 103:1262-1271.

（10）lin zhang^#, chang chen^#, jiaxin duanmu, yan wu, jinhua tao, aihua yang, xiaoqin yin, biao xiong, jingya gu, chunling li, zhaoguo liu ^*（通讯作者）. cryptotanshinone inhibits the growth and invasion of colon cancer by suppressing inflammation and tumor angiogenesis through modulating mmp/timp system, pi3k/akt/mtor signaling and hif-1α nuclear translocation [j]. international immunopharmacology, 2018, 65: 429-437.

（11）pingting zhu^#, yu wu^#, aihua yang, xingsheng fu, ming mao, zhaoguo liu^*（通讯作者）. catalpol suppressed proliferation, growth and invasion of ct26 colon cancer by inhibiting inflammation and tumor angiogenesis [j]. biomedicine & pharmacotherapy, 2017, 95:68-76.

（12）zhaoguo liu^#（第一作者）, hongyan wu^#, zhonghong wei, xu wang, peiliang shen, siliang wang, aiyun wang, wenxing chen, yin lu^*. trpm8: a potential target for cancer treatment [j]. j cancer res clin oncol, 2016, 142(9):1871-1881.

社会学术兼职：

江苏省药理学会临床前药理专委会委员

江苏省双创人才（科技副总）

frontiers in bioscience-landmark杂志编委

所获奖项及荣誉：

南通市首届十佳中药年度人物（2022）

南通大学第十二届青年教师讲课竞赛一等奖（2021）

南通大学优秀教育工作者（2021）

参编著作：

《血管生成研究方法与技术》（专著），人民卫生出版社，编委。

授权发明专利：

刘兆国，杨圣菊，彭晓露，陈畅，顾静雅. 白桦醇及其衍生物在制备抗肿瘤药物中的应用，专利号：zl201910201989.5