王磊-yb体育官方

师资介绍

王磊，男，汉族，1989年3月生，博士，讲师。

 研究方向：

非天然核酸药物和小分子药物创制

 基金项目：

1.江苏省“双创博士”项目

2.南通大学高层次人才项目

3.大学生创新创业计划项目（指导教师）

4.南通大学大型仪器开放基金

代表性论文：

1. the development of non-natural type nucleoside to stabilize triplex dna formation against cg and ta inversion site, curr. med. chem., 2024,

2. inhibition of transcription and antiproliferative effects in a cancer cell line using antigene oligonucleotides containing artificial nucleoside analogues, rsc med. chem., 2023, 14, 1482-1491.

3. enhancement of the utilization of antigene oligonucleotides in the nucleus using booster oligonucleotides, chem. comm., 2020, 56 (67), 9731-9734.

4. modification of the aminopyridine unit of 2'-deoxyaminopyridinyl-pseudocytidine allowing triplex formation at cg interruptions in homopurine sequences, nucleic acids res., 2018, 46 (17), 8679-8688.

5. effect of the 3-halo substitution of the 2’- deoxy aminopyridinyl-pseudocytidine derivatives on the selectivity and stability of antiparallel triplex dna with a cg inversion site, bioorg. med. chem., 2017, 25(14), 3853-3860.