王芸芸-yb体育官方
师资介绍
王芸芸，女，1991.01，讲师，博士研究生，专任教师
研究方向：主要从事天然产物的结构修饰、靶点的发现以及基于计算机辅助药物设计的研究。
基金项目：
1、江苏省自然科学基金项目, 青年基金项目，bk20220611，2022.0—2025.06，主持，在研；
2、南通大学人才引进项目，2022.5-2025.04，主持，在研；
3、国家自然科学基金委员会, 地区科学基金项目, 32260370, 2023.01— 2026.12, 在研, 参与；
4、国家自然科学基金委员会, 面上项目, 32071707, 2021.01—2024.12, 在研, 参与。
代表性论文：
(1) jianmin wang, jiashun mao, meng wang, xiangyang le, yunyun wang*. learning to design drug-like molecules in three-dimensional space using deep generative models, methods, 2023, 210: 52-59;
(2) jiashun mao*, jianmin wang, amir zeb, kwang-hwi cho, kwang-hwi cho, haiyan jin, jongwan kim, onju lee, yunyun wang*, and kyoung tai no*. transformer-based molecular generative model for antiviral drug design. j. chem. inf. model. 2023, .
(3) zhongyuan xu, jianqiang qian, chi meng, yun liu, qian ding, hongmei wu, peng li, fansheng ran, gongqing liu, yunyun wang*, yong ling*. tme-targeting theranostic agent uses nir tracking for tumor diagnosis and surgical resection and acts as chemotherapeutic showing enhanced efficiency and minimal toxicity, theranostics, 2022, 12(6): 2535-2548;
(4) yunyun wang, wei shi, yuxun zhao, chenglong zhang, lin wan, chenliang wu, wen gu, shifa wang*. pyrazole ring-containing isolongifolanone derivatives as potential cdk2 inhibitors: evaluation of anticancer activity and investigation of action mechanism, biomedicine &pharmacotherapy, 2021, 139: 111663;
(5) yunyun wang, zhonglong wang, hongbo kuang, yan zhang, wen gu, yongqiang zhu, shifa wang. synthesis and antitumor activity of 2-isocamphanyl thiosemicarbazone derivatives via ros-enhanced mitochondria damage, chemical biology & drug design, 2019, 94(1): 1281-1291;
(6) yunyun wang, qiangjian zhang, chenliang wu, wen gu, yu shan, shifa wang*. design, synthesis and biological evaluation of novel β-pinene-based thiazole derivatives as potential anticancer agents via mitochondrial-mediated apoptosis pathway. bioorganic chemistry, 2019, 84: 468-477.
(7) yunyun wang, wen gu, yu shan, fei liu, xu xu, yiqin yang, qiangjian zhang, yan zhang, hongbo kuang, zhonglong wang, shifa wang*. design, synthesis and anticancer activity of novel nopinone-based thiosemicarbazone derivatives. bioorganic & medicinal chemistry letters, 2017, 27(11), 2360-2363.