朱清-yb体育官方
师资介绍
姓名：朱清
性别：男
出生年月：1978.08
学历：医学博士
职称：教授；博士生导师（特种医学研究院）
职务：天然药物与药物分析系主任
邮箱：zhuqing@ntu.edu.cn
研究方向：
天然镇痛药物研发；药物动力学以及代谢组学研究
学术兼职：
frontiers in pharmacology评审编辑
教育部学位中心硕士研究生论文盲审专家
多种sci杂志审稿人
科研项目：
1. 国家自然科学基金面上项目，82071238，基于疼痛抑制行为探讨去甲青藤碱靶向α2-gabaa受体的镇痛效应，2021/01-2024/12，55万，在研，主持（pi）
2. 江苏省自然科学基金面上项目，bk20181459，基于疼痛抑制行为的去甲青藤碱镇痛效应及与gabaa受体相关机制研究，2018/07-2021/06，10万，结题，主持（pi）
3. 江苏省自然科学青年基金项目，bk20181459，益母草碱抗心肌缺血作用及药效物质基础的代谢组学研究，2013/07-2016/06，20万，结题，主持（pi）
4. 国家自然科学基金面上项目，81971243，taar1-camkii-creb信号通路调节尼古丁成瘾，2020/01-2023/12，55万，在研，副主持（co-pi）
5. 国家自然科学基金面上项目，81373390，选择性咪唑啉i2受体配体的镇痛效应及滥用潜力研究，2014/01-2017/12，65万元，结题，副主持（co-pi）
6. 中国博士后自然科学基金面上项目，2016m591898, ，2016/05-2019/05，5万元，结题，主持（pi）
代表性论文：
1. lulu yu, xunjia qian, yiheng feng, yujian yin, xiao-dan zhang, qianqian wei, liyun wang, weiwei rong, jie-jia li, jun-xu li*, qing zhu*. investigation of preclinical pharmacokinetics of n-demethylsinomenine, a potential novel analgesic candidate, using an uplc-ms/ms quantification method. front chem. 2023, 11:1222560. doi: 10.3389/fchem.2023.1222560. （通讯作者）
2. huixiao duo*, jiayuan yue, yujian yin, xiaoyu xu, liyun wang, lulu yu, xunjia qian, jiejia li, qing zhu*.magnetic carbon nanoparticles derived from co-based metal-organic frameworks for magnetic solid-phase extraction and determination of phenylurea herbicides. microchem. j., 2023, 185:108190.（通讯作者）
3. weiwei rong, jiejia li, dingyi pan, qinbei zhou, yexuan zhang, qianxing lu, liyun wang, andong wang, yizhun zhu*, qing zhu*. cardioprotective mechanism of leonurine against myocardial ischemia through a liver–cardiac crosstalk metabolomics study. biomolecules, 2022, 12, 1512. （通讯作者）
4. feifeng yang, yue zhu, congyu zhang, ziyan yang, jia yuan, qing zhu*, shushu ding*. a highly sensitive and selective artificial nanochannel for in situ detection of hydroxyl radicals in single living cell. anal. chim. acta., 2022 1235:340537（通讯作者）
5. weiwei rong, jiejia li, lifeng wang, shanshan luo, tulu liang, xunjia qian, xiaodan zhang, qinbei zhou, yizhun zhu*, qing zhu*. investigation of the protective mechanism of leonurine against acute myocardial ischemia by an integrated metabolomics and network pharmacology strategy. front. cardiovasc. med., 2022, 9: 969553.（通讯作者）
6. ming-cong zheng, wen-ting tang, lu-lu yu, xun-jia qian, jie ren, jie-jia li, wei-wei rong, jun-xu li and qing zhu*. preclinical pharmacokinetics and bioavailability of oxypeucedanin in rats after single intravenous and oral administration. molecules, 2022, 27, 3570.（通讯作者）
7. xiaohua pan#, qing zhu#, li-long pan*, jia sun*. macrophage immunometabolism in inflammatory bowel diseases: from pathogenesis to therapy. pharmacol. & ther., 2022，238: 108176. （共同第一作者）
8. zhiyong zhou, nanqing qiu, yuntao ou, qianqianwei, wentingtang, mingcong zheng, yaluan xing, jie‑jia li, yong ling, junxu li* & qing zhu*. n‑demethylsinomenine, an active metabolite of sinomenine, attenuates chronic neuropathic and infammatory pain in mice. sci. rep., 2021, 11:9300. （通讯作者）
9. yuntao ou, man su, yong ling, qianqian wei, fei pan, jiejia li, jun-xu li*, qing zhu*. anti-allodynic effects of n-demethylsinomenine, an active metabolite of sinomenine, in a mouse model of postoperative pain. eur. j. pharmacol. 2018, 823:105–109. （通讯作者）
10. yong ling, jing guo, qiuxing yang, peng zhu, jiefei miao, weijie gao, yanfu peng, jiaying yang, kun xu, biao xiong, gongqing liu, jinhua tao, lin luo, qing zhu*, yanan zhang*. development of novel β-carboline-based hydroxamate derivatives as hdac inhibitors with antiproliferative and antimetastatic activities in human cancer cells. eur. j. med. chem., 2018, 144:398-409. （通讯作者）
11. qing zhu, yuehua sun, lina mao, chengpeng liu, bo jiang, wei zhang & jun-xu li. antinociceptive effects of sinomenine in a rat model of postoperative pain，brit. j. pharmacol., 2016, 173:1693-1702.
12. qing zhu, li-na mao, cheng-peng liu, yue-hua sun, bo jiang, wei zhang & jun-xu li. antinociceptive effects of vitexin in a mouse model of postoperative pain. sci. rep., 2016, 6:19266.
13. qing zhu, yuehua sun, jie zhu, tian fang, wei zhang & jun-xu li. antinociceptive effects of sinomenine in a rat model of neuropathic pain. sci. rep., 2014, 4: 7270.
14. qing zhu, yuehua sun, xiaodi yun, yuntao ou, wei zhang & jun-xu li. antinociceptive effects of curcumin in a rat model of postoperative pain, sci. rep., 2014, 4:4932.
15. qing zhu, jinlian zhang, ping yang, bo tan, xinhua liu, yuanting zheng, weimin cai & yizhun zhu. characterization of metabolites of leonurine (scm-198) in rats after oral administration by liquid chromatography/tandem mass spectrometry and nmr spectrometry, sci. world j., 2014, 2014:947946.
16. qing zhu, weimin cai, xianyi sha, guo ma, yuanting zheng, xueru shi & yizhun zhu. quantification of leonurine, a novel potential cardiovascular agent, in rat plasma by liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic study in rats, biomed. chromatogr., 2012, 26(4): 518-523.
17. jie-jia li#, qing zhu#, ya-peng lu, peng zhao, zhan-bo feng, zhong-ming qian & li zhu. ligustilide prevents cognitive impairment and attenuates neurotoxicity in d-galactose induced aging mice brain, brain res., 2015,1595:19-28. （共同第一作者）
18. donggeng wang#, qing zhu #, baohua liu, guangtong chen & yong ling. identification of gut microbial metabolites of a synthetic nitric oxide-releasing farnesylthiosalicylic acid derivative, an antitumor agent, anal. lett., 2014, 47(2):191-201.（共同第一作者）
19. qing zhu, jinhua gu, hongyan zhu & jiliang xu. identification of differentially expressed genes in dorsal root ganglion in early diabetic rats, neurosci. bull., 2008, 24(4):219-24.
授权发明专利
1. zhu, qing, et al. anlagesic drug composition. 2020/12/18, nigeria，ng/pt/c/2020/4763.
2. 朱清，李俊旭，苏漫，李洁佳，欧云淘，一种镇痛药物组合物，2021/03/19
中国，zl201710671939.4
3. 朱清，卫蒨蒨，唐文婷，李俊旭，潘菲，邱男青，周致用，李洁佳，氧化前胡素的新用途，2020/05/08，中国zl201810813028.5
4. 朱清，李俊旭，卫蒨蒨，潘菲，邱男青，李洁佳，氧化前胡素在制备治疗术后疼痛药物中的应用，2020/04/28，中国zl201810751676.2
5. 朱清，李俊旭，孙越华，青藤碱在制备治疗慢性疼痛伴抑郁行为药物中的应用，2017/01/04，中国，zl201410456667.2
6. 李俊旭，朱清，欧云淘，苏漫，赵颖，去甲青藤碱在制备镇痛药物中的应用，2019/12/20 中国，zl201610331233.9
7. 李俊旭，朱清，毛丽娜，刘成鹏，孙越华，牡荆素在制备治疗术后疼痛中的应用，2017.11.07，中国，zl201510642790.8
获奖情况：
2023年荣获南通市药学会优秀学术带头人奖；
2022年南通大学“互联网”大学生创业大赛二等奖（指导教师）
2015年获南通市科学技术进步奖二等奖（排名第四）；
2011年获南通大学2011届毕业设计（论文）优秀指导教师